2a0b

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[[Image:2a0b.jpg|left|200px]]
 
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{{Structure
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==HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI==
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|PDB= 2a0b |SIZE=350|CAPTION= <scene name='initialview01'>2a0b</scene>, resolution 1.57&Aring;
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<StructureSection load='2a0b' size='340' side='right'caption='[[2a0b]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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|SITE= <scene name='pdbsite=PHB:Phosphorylation+Site'>PHB</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2a0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A0B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a0b OCA], [https://pdbe.org/2a0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a0b RCSB], [https://www.ebi.ac.uk/pdbsum/2a0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a0b ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a0b OCA], [http://www.ebi.ac.uk/pdbsum/2a0b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a0b RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/ARCB_ECOLI ARCB_ECOLI] Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576.
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== Evolutionary Conservation ==
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'''HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/2a0b_consurf.spt"</scriptWhenChecked>
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The crystal structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli has been refined to 1.57 A resolution, using the coordinates of the earlier 2.06 A structure as a starting model. The final model contained 956 protein atoms, one zinc ion and 156 water molecules, with an R factor of 19.0%. The high-resolution electron-density maps clearly revealed additional solvent molecules and seven discrete rotamers in the protein side chains. One residue, Met755, was fully buried but was able to occupy the space in the hydrophobic core by means of the two-state conformation of its side chain. One water molecule was buried in the protein core and contributed to the rigidity of the HPt domain, cooperating in the coordination of the zinc ion.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2A0B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0B OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a0b ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Refined structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli at 1.57 A resolution., Kato M, Mizuno T, Shimizu T, Hakoshima T, Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1842-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10531481 10531481]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hakoshima, T.]]
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[[Category: Hakoshima T]]
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[[Category: Kato, M.]]
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[[Category: Kato M]]
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[[Category: Mizuno, T.]]
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[[Category: Mizuno T]]
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[[Category: Shimizu, T.]]
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[[Category: Shimizu T]]
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[[Category: four-helix bundle]]
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[[Category: histidine kinase]]
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[[Category: phosphotransfer]]
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[[Category: sensory transduction]]
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[[Category: two-component system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:46:12 2008''
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Current revision

HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI

PDB ID 2a0b

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