6bgh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR structure of Brd3 ET domain bound to Brg1 peptide== | |
| + | <StructureSection load='6bgh' size='340' side='right'caption='[[6bgh]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6bgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BGH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bgh OCA], [https://pdbe.org/6bgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bgh RCSB], [https://www.ebi.ac.uk/pdbsum/6bgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bgh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mackay JP]] | ||
| + | [[Category: Szyszka TN]] | ||
| + | [[Category: Wai DC]] | ||
Current revision
Solution NMR structure of Brd3 ET domain bound to Brg1 peptide
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