3mk8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:26, 30 October 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer==
==The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer==
-
<StructureSection load='3mk8' size='340' side='right' caption='[[3mk8]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
+
<StructureSection load='3mk8' size='340' side='right'caption='[[3mk8]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3mk8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MK8 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3mk8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MK8 FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.321&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L3, MCL-1, MCL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mk8 OCA], [http://pdbe.org/3mk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3mk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mk8 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mk8 OCA], [https://pdbe.org/3mk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3mk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mk8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
+
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/3mk8_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/3mk8_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 29: Line 29:
</div>
</div>
<div class="pdbe-citations 3mk8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3mk8" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Fire, E]]
+
[[Category: Large Structures]]
-
[[Category: Keating, A E]]
+
[[Category: Fire E]]
-
[[Category: Stewart, M]]
+
[[Category: Keating AE]]
-
[[Category: Walensky, L D]]
+
[[Category: Stewart M]]
-
[[Category: Anti-apoptotic]]
+
[[Category: Walensky LD]]
-
[[Category: Apoptosis]]
+
-
[[Category: Apoptosis-apoptosis regulator complex]]
+
-
[[Category: Bcl-2 family]]
+
-
[[Category: Mcl-1]]
+
-
[[Category: Mcl-1 sahb d]]
+
-
[[Category: Sahb]]
+
-
[[Category: Staple]]
+

Current revision

The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer

PDB ID 3mk8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mk8"
Personal tools