3ps1

<StructureSection load='3ps1' size='340' side='right' caption='[[3ps1]], [[Resolution|resolution]] 1.85&Aring;' scene=''>

<table><tr><td colspan='2'>[[3ps1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoki Ecoki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PS1 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZH2:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BENZAMIDE'>ZH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 ECOKI])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ps1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps1 OCA], [http://pdbe.org/3ps1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ps1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ps1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ps1 ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS004463_004_013136]

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== Publication Abstract from PubMed ==

Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-butadiyne) threonyl-hydroxamate scaffold. These studies provide a molecular interpretation for the differential antibiotic activities of compounds with a substituted distal phenyl ring as well as the absolute stereochemical requirement at the C2, but not C3, position of the threonyl group.

 

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== References ==

[[Category: Ecoki]]

[[Category: Lee, C J]]

[[Category: Zhou, P]]

[[Category: Acyl udp-glcnac]]

[[Category: Antibiotic]]

[[Category: Lpc-011]]