3v6b

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==VEGFR-2/VEGF-E complex structure==
==VEGFR-2/VEGF-E complex structure==
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<StructureSection load='3v6b' size='340' side='right' caption='[[3v6b]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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<StructureSection load='3v6b' size='340' side='right'caption='[[3v6b]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v6b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Contagious_pustular_dermatitis_virus Contagious pustular dermatitis virus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v6b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Orf_virus Orf virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6B FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gnn|2gnn]], [[2x1w|2x1w]], [[2x1x|2x1x]], [[3v2a|3v2a]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.205&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KDR, FLK1, VEGFR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6b OCA], [https://pdbe.org/3v6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6b RCSB], [https://www.ebi.ac.uk/pdbsum/3v6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6b ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6b OCA], [http://pdbe.org/3v6b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v6b RCSB], [http://www.ebi.ac.uk/pdbsum/3v6b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6b ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/VGFR2_HUMAN VGFR2_HUMAN]] Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:[http://omim.org/entry/602089 602089]]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.<ref>PMID:11807987</ref> <ref>PMID:18931684</ref> Note=Plays a major role in tumor angiogenesis. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VGFR2_HUMAN VGFR2_HUMAN]] Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.<ref>PMID:19668192</ref> <ref>PMID:1417831</ref> <ref>PMID:7929439</ref> <ref>PMID:9160888</ref> <ref>PMID:9837777</ref> <ref>PMID:9804796</ref> <ref>PMID:10600473</ref> <ref>PMID:10102632</ref> <ref>PMID:11387210</ref> <ref>PMID:12649282</ref> <ref>PMID:15026417</ref> <ref>PMID:15215251</ref> <ref>PMID:15962004</ref> <ref>PMID:16966330</ref> <ref>PMID:17303569</ref> <ref>PMID:19834490</ref> <ref>PMID:20179233</ref> <ref>PMID:20224550</ref> <ref>PMID:20705758</ref> <ref>PMID:10368301</ref> <ref>PMID:18529047</ref> <ref>PMID:20080685</ref>
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[https://www.uniprot.org/uniprot/VEGFH_ORFN2 VEGFH_ORFN2] Induces endothelial proliferation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3v6b" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3v6b" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[VEGF 3D Structures|VEGF 3D Structures]]
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*[[3D structures of vascular endothelial growth factor receptor|3D structures of vascular endothelial growth factor receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Contagious pustular dermatitis virus]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Ballmer-Hofer, K]]
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[[Category: Brozzo, M S]]
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[[Category: Kisko, K]]
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[[Category: Leppanen, V M]]
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[[Category: Winkler, F K]]
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[[Category: Angiogenesis]]
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[[Category: Growth factor receptor]]
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[[Category: Hormone-signaling protein complex]]
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[[Category: Ig-homology domain]]
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[[Category: Membrane]]
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[[Category: Orf virus]]
[[Category: Orf virus]]
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[[Category: Vegf ligand]]
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[[Category: Ballmer-Hofer K]]
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[[Category: Vegf-e]]
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[[Category: Brozzo MS]]
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[[Category: Vegfr-2]]
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[[Category: Kisko K]]
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[[Category: Leppanen V-M]]
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[[Category: Winkler FK]]

Current revision

VEGFR-2/VEGF-E complex structure

PDB ID 3v6b

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