5yqm
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5yqm is ON HOLD Authors: Wang, H., Yu, Y., Li, G., chen, Q. Description: Crystal structure of Sirt2 in complex with selective inhibitor A29 [[Categ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Sirt2 in complex with selective inhibitor A29== | |
| + | <StructureSection load='5yqm' size='340' side='right'caption='[[5yqm]], [[Resolution|resolution]] 1.73Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5yqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YQM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.735Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2X:2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide'>A2X</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yqm OCA], [https://pdbe.org/5yqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yqm RCSB], [https://www.ebi.ac.uk/pdbsum/5yqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yqm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Li G]] | ||
| + | [[Category: Wang H]] | ||
| + | [[Category: Yu Y]] | ||
| + | [[Category: Chen Q]] | ||
Current revision
Crystal structure of Sirt2 in complex with selective inhibitor A29
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Categories: Homo sapiens | Large Structures | Li G | Wang H | Yu Y | Chen Q
