2adc

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[[Image:2adc.gif|left|200px]]
 
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{{Structure
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==Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA==
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|PDB= 2adc |SIZE=350|CAPTION= <scene name='initialview01'>2adc</scene>
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<StructureSection load='2adc' size='340' side='right'caption='[[2adc]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[2adc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ADC FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= PTB-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adc OCA], [https://pdbe.org/2adc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adc RCSB], [https://www.ebi.ac.uk/pdbsum/2adc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adc ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[2ad9|2AD9]], [[2adb|2ADB]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adc OCA], [http://www.ebi.ac.uk/pdbsum/2adc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2adc RCSB]</span>
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[https://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2adc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2adc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.
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'''Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA'''
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Structure of PTB bound to RNA: specific binding and implications for splicing regulation.,Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH Science. 2005 Sep 23;309(5743):2054-7. PMID:16179478<ref>PMID:16179478</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2adc" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2ADC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADC OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Structure of PTB bound to RNA: specific binding and implications for splicing regulation., Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH, Science. 2005 Sep 23;309(5743):2054-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16179478 16179478]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Allain, F H.T.]]
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[[Category: Allain FHT]]
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[[Category: Auweter, S D.]]
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[[Category: Auweter SD]]
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[[Category: Black, D L.]]
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[[Category: Black DL]]
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[[Category: Erat, M.]]
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[[Category: Erat M]]
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[[Category: Hargous, Y.]]
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[[Category: Hargous Y]]
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[[Category: Henning, A.]]
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[[Category: Henning A]]
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[[Category: Oberstrass, F C.]]
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[[Category: Oberstrass FC]]
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[[Category: Pitsch, S.]]
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[[Category: Pitsch S]]
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[[Category: Reymond, L.]]
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[[Category: Reymond L]]
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[[Category: Wenter, P.]]
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[[Category: Wenter P]]
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[[Category: protein-rna complex]]
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[[Category: rbd]]
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[[Category: rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:51:03 2008''
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Current revision

Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA

PDB ID 2adc

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