6bku
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6bku is ON HOLD Authors: Counago, R.M., dos Reis, C.V., de Souza, G.P., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Structural Genomics C...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Human CAMKK2B bound to GSK650394== | |
| + | <StructureSection load='6bku' size='340' side='right'caption='[[6bku]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6bku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BKU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXV:2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic+acid'>DXV</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bku OCA], [https://pdbe.org/6bku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bku RCSB], [https://www.ebi.ac.uk/pdbsum/6bku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bku ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Massirer | + | [[Category: Arruda P]] |
| - | [[Category: | + | [[Category: Counago RM]] |
| - | [[Category: De Souza | + | [[Category: Drewry D]] |
| - | [[Category: Dos Reis | + | [[Category: Edwards AM]] |
| + | [[Category: Elkins JM]] | ||
| + | [[Category: Massirer KB]] | ||
| + | [[Category: Ramos PZ]] | ||
| + | [[Category: De Souza GP]] | ||
| + | [[Category: Dos Reis CV]] | ||
Current revision
Crystal Structure of the Human CAMKK2B bound to GSK650394
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Categories: Homo sapiens | Large Structures | Arruda P | Counago RM | Drewry D | Edwards AM | Elkins JM | Massirer KB | Ramos PZ | De Souza GP | Dos Reis CV
