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6bku

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'''Unreleased structure'''
 
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The entry 6bku is ON HOLD
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==Crystal Structure of the Human CAMKK2B bound to GSK650394==
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<StructureSection load='6bku' size='340' side='right'caption='[[6bku]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BKU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXV:2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic+acid'>DXV</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bku OCA], [https://pdbe.org/6bku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bku RCSB], [https://www.ebi.ac.uk/pdbsum/6bku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bku ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
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Authors: Counago, R.M., dos Reis, C.V., de Souza, G.P., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]]
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Description: Crystal Structure of the Human CAMKK2B bound to GSK650394
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Drewry, D]]
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__TOC__
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[[Category: Edwards, A.M]]
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</StructureSection>
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[[Category: Arruda, P]]
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[[Category: Homo sapiens]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Large Structures]]
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[[Category: Massirer, K.B]]
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[[Category: Arruda P]]
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[[Category: Counago, R.M]]
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[[Category: Counago RM]]
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[[Category: De Souza, G.P]]
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[[Category: Drewry D]]
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[[Category: Dos Reis, C.V]]
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[[Category: Edwards AM]]
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[[Category: Elkins JM]]
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[[Category: Massirer KB]]
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[[Category: Ramos PZ]]
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[[Category: De Souza GP]]
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[[Category: Dos Reis CV]]

Current revision

Crystal Structure of the Human CAMKK2B bound to GSK650394

PDB ID 6bku

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