2aeo

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[[Image:2aeo.gif|left|200px]]
 
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{{Structure
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==Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase==
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|PDB= 2aeo |SIZE=350|CAPTION= <scene name='initialview01'>2aeo</scene>, resolution 1.80&Aring;
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<StructureSection load='2aeo' size='340' side='right'caption='[[2aeo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NCP:CIS-DIAMINODICHLOROPLATINUM'>NCP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2aeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AEO FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeo OCA], [https://pdbe.org/2aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aeo RCSB], [https://www.ebi.ac.uk/pdbsum/2aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeo ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1sxs|1SXS]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeo OCA], [http://www.ebi.ac.uk/pdbsum/2aeo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aeo RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/SODC_BOVIN SODC_BOVIN] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2aeo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aeo ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase'''
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==See Also==
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2AEO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEO OCA].
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==Reference==
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Structural investigation of cisplatin-protein interactions: selective platination of His19 in a cuprozinc superoxide dismutase., Calderone V, Casini A, Mangani S, Messori L, Orioli PL, Angew Chem Int Ed Engl. 2006 Feb 13;45(8):1267-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16416478 16416478]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Superoxide dismutase]]
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[[Category: Calderone V]]
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[[Category: Calderone, V.]]
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[[Category: Casini A]]
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[[Category: Casini, A.]]
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[[Category: Mangani S]]
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[[Category: Mangani, S.]]
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[[Category: Messori L]]
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[[Category: Messori, L.]]
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[[Category: Orioli PL]]
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[[Category: Orioli, P L.]]
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[[Category: cancer]]
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[[Category: cisplatin]]
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[[Category: cu,zn sod]]
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[[Category: metal based drug]]
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[[Category: platinum]]
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[[Category: protein]]
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[[Category: sod]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:51:39 2008''
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Current revision

Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase

PDB ID 2aeo

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