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5vt7

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ABA-mimicking ligand AMC1beta in complex with ABA receptor PYL2 and PP2C HAB1

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 ==ABA-mimicking ligand AMC1beta in complex with ABA receptor PYL2 and PP2C HAB1==
-<StructureSection load='5vt7' size='340' side='right' caption='[[5vt7]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
+<StructureSection load='5vt7' size='340' side='right'caption='[[5vt7]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5vt7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VT7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5vt7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VT7 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A1C:1-(3-chloro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide'>A1C</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.624&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vro|5vro]], [[5vr7|5vr7]], [[5vsq|5vsq]], [[5vsr|5vsr]], [[5vs5|5vs5]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C:1-(3-chloro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide'>A1C</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vt7 OCA], [https://pdbe.org/5vt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vt7 RCSB], [https://www.ebi.ac.uk/pdbsum/5vt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vt7 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vt7 OCA], [http://pdbe.org/5vt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vt7 RCSB], [http://www.ebi.ac.uk/pdbsum/5vt7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vt7 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>  [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
+[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Drought stress is a major threat to crop production, but effective methods to mitigate the adverse effects of drought are not available. Here, we report that adding fluorine atoms in the benzyl ring of the abscisic acid (ABA) receptor agonist AM1 optimizes its binding to ABA receptors by increasing the number of hydrogen bonds between the compound and the surrounding amino acid residues in the receptor ligand-binding pocket. The new chemicals, known as AMFs, have long-lasting effects in promoting stomatal closure and inducing the expression of stress-responsive genes. Application of AMFs or transgenic overexpression of the receptor PYL2 in Arabidopsis and soybean plants confers increased drought resistance. The greatest increase in drought resistance is achieved when AMFs are applied to the PYL2-overexpression transgenic plants. Our results demonstrate that the combining of potent chemicals with transgenic overexpression of an ABA receptor is very effective in helping plants combat drought stress.
-Combining chemical and genetic approaches to increase drought resistance in plants.,Cao MJ, Zhang YL, Liu X, Huang H, Zhou XE, Wang WL, Zeng A, Zhao CZ, Si T, Du J, Wu WW, Wang FX, Xu HE, Zhu JK Nat Commun. 2017 Oct 30;8(1):1183. doi: 10.1038/s41467-017-01239-3. PMID:29084945<ref>PMID:29084945</ref>
+==See Also==
+*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
-</div>
-<div class="pdbe-citations 5vt7" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Phosphoprotein phosphatase]]
+[[Category: Arabidopsis thaliana]]
-[[Category: Cao, M J]]
+[[Category: Large Structures]]
-[[Category: Du, J M]]
+[[Category: Cao M-J]]
-[[Category: Huang, H]]
+[[Category: Du J-M]]
-[[Category: Liu, X]]
+[[Category: Huang H]]
-[[Category: Si, T]]
+[[Category: Liu X]]
-[[Category: Wang, F X]]
+[[Category: Si T]]
-[[Category: Wang, W L]]
+[[Category: Wang F-X]]
-[[Category: Wu, W W]]
+[[Category: Wang W-L]]
-[[Category: Xu, H X]]
+[[Category: Wu W-W]]
-[[Category: Zeng, A]]
+[[Category: Xu HX]]
-[[Category: Zhang, Y L]]
+[[Category: Zeng A]]
-[[Category: Zhao, C Z]]
+[[Category: Zhang Y-L]]
-[[Category: Zhou, X E]]
+[[Category: Zhao C-Z]]
-[[Category: Zhu, J K]]
+[[Category: Zhou XE]]
-[[Category: Aba]]
+[[Category: Zhu J-K]]
-[[Category: Agonist]]
-[[Category: Amf]]
-[[Category: Drought resistance]]
-[[Category: Hydrolase]]
-[[Category: Receptor]]

5vt7

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ABA-mimicking ligand AMC1beta in complex with ABA receptor PYL2 and PP2C HAB1

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