6b5b

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==Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome==
==Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome==
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<StructureSection load='6b5b' size='340' side='right' caption='[[6b5b]], [[Resolution|resolution]] 5.20&Aring;' scene=''>
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<SX load='6b5b' size='340' side='right' viewer='molstar' caption='[[6b5b]], [[Resolution|resolution]] 5.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b5b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B5B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B5B FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b5b OCA], [http://pdbe.org/6b5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b5b RCSB], [http://www.ebi.ac.uk/pdbsum/6b5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b5b ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b5b OCA], [https://pdbe.org/6b5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b5b RCSB], [https://www.ebi.ac.uk/pdbsum/6b5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b5b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BIR1E_MOUSE BIR1E_MOUSE]] Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals.<ref>PMID:21874021</ref> <ref>PMID:21918512</ref> [[http://www.uniprot.org/uniprot/G8UUW9_LEGPN G8UUW9_LEGPN]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.[RuleBase:RU362073] [[http://www.uniprot.org/uniprot/NLRC4_MOUSE NLRC4_MOUSE]] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip5): specific Naip proteins recognize and bind pathogenic proteins, driving assembly and activation of the NLRC4 inflammasome. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri and fungal pathogen C.albicans. In intestine, the NLRC4 inflammasome is able to discriminate between commensal and pathogenic bacteria and specifically drives production of interleukin-1 beta (IL1B) in response to infection by Salmonella or P.aeruginosa. In case of L.pneumophila infection the inflammasome acts by activating caspase-7.<ref>PMID:15190255</ref> <ref>PMID:16648853</ref> <ref>PMID:16648852</ref> <ref>PMID:18070936</ref> <ref>PMID:19343209</ref> <ref>PMID:20603313</ref> <ref>PMID:20133635</ref> <ref>PMID:21874021</ref> <ref>PMID:21918512</ref> <ref>PMID:22174673</ref> <ref>PMID:22547706</ref> <ref>PMID:22231517</ref> <ref>PMID:22484733</ref> <ref>PMID:22885697</ref>
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[https://www.uniprot.org/uniprot/NLRC4_MOUSE NLRC4_MOUSE] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip5): specific Naip proteins recognize and bind pathogenic proteins, driving assembly and activation of the NLRC4 inflammasome. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri and fungal pathogen C.albicans. In intestine, the NLRC4 inflammasome is able to discriminate between commensal and pathogenic bacteria and specifically drives production of interleukin-1 beta (IL1B) in response to infection by Salmonella or P.aeruginosa. In case of L.pneumophila infection the inflammasome acts by activating caspase-7.<ref>PMID:15190255</ref> <ref>PMID:16648853</ref> <ref>PMID:16648852</ref> <ref>PMID:18070936</ref> <ref>PMID:19343209</ref> <ref>PMID:20603313</ref> <ref>PMID:20133635</ref> <ref>PMID:21874021</ref> <ref>PMID:21918512</ref> <ref>PMID:22174673</ref> <ref>PMID:22547706</ref> <ref>PMID:22231517</ref> <ref>PMID:22484733</ref> <ref>PMID:22885697</ref>
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==See Also==
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*[[Flagellin 3D structures|Flagellin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Adamson, E]]
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[[Category: Large Structures]]
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[[Category: Bourgeois, N M]]
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[[Category: Legionella pneumophila]]
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[[Category: Chacon, P]]
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[[Category: Mus musculus]]
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[[Category: Grob, P]]
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[[Category: Adamson E]]
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[[Category: Haloupek, N]]
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[[Category: Bourgeois NM]]
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[[Category: Hartenian, E]]
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[[Category: Chacon P]]
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[[Category: Lind, N A]]
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[[Category: Grob P]]
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[[Category: Lopez-Blanco, J R]]
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[[Category: Haloupek N]]
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[[Category: Nogales, E]]
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[[Category: Hartenian E]]
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[[Category: Tenthorey, J L]]
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[[Category: Lind NA]]
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[[Category: Vance, R E]]
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[[Category: Lopez-Blanco JR]]
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[[Category: Immune system]]
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[[Category: Nogales E]]
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[[Category: Innate immunity]]
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[[Category: Tenthorey JL]]
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[[Category: Molecular complex]]
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[[Category: Vance RE]]

Current revision

Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome

6b5b, resolution 5.20Å

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