We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

6ero

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:31, 1 May 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Structure of human TFB2M==
==Structure of human TFB2M==
-
<StructureSection load='6ero' size='340' side='right' caption='[[6ero]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+
<StructureSection load='6ero' size='340' side='right'caption='[[6ero]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6ero]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERO FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6ero]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ERO FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ero FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ero OCA], [http://pdbe.org/6ero PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ero RCSB], [http://www.ebi.ac.uk/pdbsum/6ero PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ero ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ero FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ero OCA], [https://pdbe.org/6ero PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ero RCSB], [https://www.ebi.ac.uk/pdbsum/6ero PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ero ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TFB2M_HUMAN TFB2M_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.<ref>PMID:12068295</ref> <ref>PMID:12897151</ref> <ref>PMID:15526033</ref> <ref>PMID:20410300</ref>
+
[https://www.uniprot.org/uniprot/TFB2M_HUMAN TFB2M_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.<ref>PMID:12068295</ref> <ref>PMID:12897151</ref> <ref>PMID:15526033</ref> <ref>PMID:20410300</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Cramer, P]]
+
[[Category: Homo sapiens]]
-
[[Category: Hillen, H S]]
+
[[Category: Large Structures]]
-
[[Category: Morozov, Y I]]
+
[[Category: Cramer P]]
-
[[Category: Sarfallah, A]]
+
[[Category: Hillen HS]]
-
[[Category: Temiakov, D]]
+
[[Category: Morozov YI]]
-
[[Category: Initiation]]
+
[[Category: Sarfallah A]]
-
[[Category: Mitochondria]]
+
[[Category: Temiakov D]]
-
[[Category: Polymerase]]
+
-
[[Category: Transcription]]
+

Current revision

Structure of human TFB2M

PDB ID 6ero

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ero"
Personal tools