4gxl

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==The crystal structure of Galectin-8 C-CRD in complex with NDP52==
==The crystal structure of Galectin-8 C-CRD in complex with NDP52==
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<StructureSection load='4gxl' size='340' side='right' caption='[[4gxl]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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<StructureSection load='4gxl' size='340' side='right'caption='[[4gxl]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GXL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GXL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.023&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxl OCA], [http://pdbe.org/4gxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gxl RCSB], [http://www.ebi.ac.uk/pdbsum/4gxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxl OCA], [https://pdbe.org/4gxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gxl RCSB], [https://www.ebi.ac.uk/pdbsum/4gxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref> [[http://www.uniprot.org/uniprot/CACO2_HUMAN CACO2_HUMAN]] May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.<ref>PMID:17635994</ref>
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[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Autophagy, the process of lysosome-dependent degradation of cytosolic components, is a mechanism by which cells selectively engulf invading pathogens to protect themselves against infection. Galectin-8, a cytosolic protein with specificity for beta-galactoside-containing glycans, binds endosomal and lysosomal membranes that have been damaged, for example, by pathogens, and selectively recruits the autophagy cargo receptor NDP52 to induce autophagy. We solved the crystal structure of the NDP52-galectin-8 complex to show how NDP52 exclusively binds galectin-8 and, consequently, why other galectins do not restrict the growth of Salmonella in human cells.
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Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy.,Li S, Wandel MP, Li F, Liu Z, He C, Wu J, Shi Y, Randow F Sci Signal. 2013 Feb 5;6(261):ra9. doi: 10.1126/scisignal.2003730. PMID:23386746<ref>PMID:23386746</ref>
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4gxl" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: He, C]]
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[[Category: Large Structures]]
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[[Category: Li, F]]
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[[Category: He C]]
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[[Category: Li, S]]
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[[Category: Li F]]
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[[Category: Liu, Z]]
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[[Category: Li S]]
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[[Category: Randow, F]]
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[[Category: Liu Z]]
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[[Category: Shi, Y]]
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[[Category: Randow F]]
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[[Category: Wandel, M P]]
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[[Category: Shi Y]]
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[[Category: Wu, J]]
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[[Category: Wandel MP]]
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[[Category: Carbohydrate recognition]]
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[[Category: Wu J]]
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[[Category: Ndp52]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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Current revision

The crystal structure of Galectin-8 C-CRD in complex with NDP52

PDB ID 4gxl

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