4jep
From Proteopedia
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==Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)== | ==Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)== | ||
| - | <StructureSection load='4jep' size='340' side='right' caption='[[4jep]], [[Resolution|resolution]] 3.10Å' scene=''> | + | <StructureSection load='4jep' size='340' side='right'caption='[[4jep]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4jep]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4jep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JEP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jep OCA], [https://pdbe.org/4jep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jep RCSB], [https://www.ebi.ac.uk/pdbsum/4jep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jep ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4jep" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4jep" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Ectonucleoside triphosphate diphosphohydrolase|Ectonucleoside triphosphate diphosphohydrolase]] | ||
| + | *[[Nucleoside triphosphatase|Nucleoside triphosphatase]] | ||
| + | *[[Sandbox 30008|Sandbox 30008]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Toxoplasma gondii]] |
| - | [[Category: Krug | + | [[Category: Krug U]] |
| - | [[Category: Strater | + | [[Category: Strater N]] |
| - | [[Category: Totzauer | + | [[Category: Totzauer R]] |
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Current revision
Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)
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