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4ky8

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==Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid==
==Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid==
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<StructureSection load='4ky8' size='340' side='right' caption='[[4ky8]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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<StructureSection load='4ky8' size='340' side='right'caption='[[4ky8]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ky8]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryho Cryho]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KY8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ky8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KY8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1UF:N-{4-[(2-AMINO-6-METHYL-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)SULFANYL]-2-CHLOROBENZOYL}-L-GLUTAMIC+ACID'>1UF</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.084&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qzf|1qzf]], [[3hj3|3hj3]], [[3dl5|3dl5]], [[3dl6|3dl6]], [[2oip|2oip]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1UF:N-{4-[(2-AMINO-6-METHYL-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)SULFANYL]-2-CHLOROBENZOYL}-L-GLUTAMIC+ACID'>1UF</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Chro.40506, TS-DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237895 CRYHO])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ky8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ky8 OCA], [https://pdbe.org/4ky8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ky8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ky8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ky8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ky8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ky8 OCA], [http://pdbe.org/4ky8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ky8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ky8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ky8 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/Q5CGA3_CRYHO Q5CGA3_CRYHO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ky8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ky8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cryho]]
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[[Category: Cryptosporidium hominis]]
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[[Category: Anderson, K S]]
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[[Category: Large Structures]]
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[[Category: Kumar, V P]]
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[[Category: Anderson KS]]
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[[Category: Bifunctional enzyme]]
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[[Category: Kumar VP]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-inhibitor complex]]
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[[Category: Transferase]]
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Current revision

Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid

PDB ID 4ky8

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