2akf

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[[Image:2akf.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the coiled-coil domain of coronin 1==
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|PDB= 2akf |SIZE=350|CAPTION= <scene name='initialview01'>2akf</scene>, resolution 1.20&Aring;
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<StructureSection load='2akf' size='340' side='right'caption='[[2akf]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2akf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AKF FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2akf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akf OCA], [https://pdbe.org/2akf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2akf RCSB], [https://www.ebi.ac.uk/pdbsum/2akf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2akf ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2akf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akf OCA], [http://www.ebi.ac.uk/pdbsum/2akf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2akf RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/COR1A_MOUSE COR1A_MOUSE] May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.<ref>PMID:10338208</ref>
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== References ==
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'''Crystal structure of the coiled-coil domain of coronin 1'''
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<references/>
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__TOC__
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</StructureSection>
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==Overview==
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[[Category: Large Structures]]
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In recent years, short coiled coils have been used for applications ranging from biomaterial to medical sciences. For many of these applications knowledge of the factors that control the topology of the engineered protein systems is essential. Here, we demonstrate that trimerization of short coiled coils is determined by a distinct structural motif that encompasses specific networks of surface salt bridges and optimal hydrophobic packing interactions. The motif is conserved among intracellular, extracellular, viral, and synthetic proteins and defines a universal molecular determinant for trimer formation of short coiled coils. In addition to being of particular interest for the biotechnological production of candidate therapeutic proteins, these findings may be of interest for viral drug development strategies.
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[[Category: Mus musculus]]
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[[Category: Avila D]]
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==About this Structure==
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[[Category: Honnappa S]]
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2AKF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKF OCA].
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[[Category: Kammerer RA]]
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[[Category: Kostrewa D]]
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==Reference==
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[[Category: Lustig A]]
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A conserved trimerization motif controls the topology of short coiled coils., Kammerer RA, Kostrewa D, Progias P, Honnappa S, Avila D, Lustig A, Winkler FK, Pieters J, Steinmetz MO, Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13891-6. Epub 2005 Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16172398 16172398]
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[[Category: Pieters J]]
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[[Category: Single protein]]
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[[Category: Progias P]]
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[[Category: Avila, D.]]
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[[Category: Steinmetz MO]]
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[[Category: Honnappa, S.]]
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[[Category: Winkler FK]]
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[[Category: Kammerer, R A.]]
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[[Category: Kostrewa, D.]]
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[[Category: Lustig, A.]]
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[[Category: Pieters, J.]]
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[[Category: Progias, P.]]
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[[Category: Steinmetz, M O.]]
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[[Category: Winkler, F K.]]
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[[Category: coiled coil]]
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[[Category: coronin 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:53:51 2008''
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Current revision

Crystal structure of the coiled-coil domain of coronin 1

PDB ID 2akf

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