1ae7

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==NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2==
==NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2==
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<StructureSection load='1ae7' size='340' side='right' caption='[[1ae7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1ae7' size='340' side='right'caption='[[1ae7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ae7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Notechis_scutatus_scutatus Notechis scutatus scutatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AE7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ae7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Notechis_scutatus_scutatus Notechis scutatus scutatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AE7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ae7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ae7 OCA], [http://pdbe.org/1ae7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ae7 RCSB], [http://www.ebi.ac.uk/pdbsum/1ae7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ae7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ae7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ae7 OCA], [https://pdbe.org/1ae7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ae7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ae7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ae7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2B_NOTSC PA2B_NOTSC]] Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. Is directly toxic to skeletal muscle upon local application in vivo (dystrophic effect). Also has direct nephrotoxicity in experimental mice; a single subcutaneous dose (1.38 ug/kg) produces renal tubular and glomerular damage within 24 hours (PubMed:7580101). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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[https://www.uniprot.org/uniprot/PA2B_NOTSC PA2B_NOTSC] Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. Is directly toxic to skeletal muscle upon local application in vivo (dystrophic effect). Also has direct nephrotoxicity in experimental mice; a single subcutaneous dose (1.38 ug/kg) produces renal tubular and glomerular damage within 24 hours (PubMed:7580101). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/1ae7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/1ae7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1ae7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1ae7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Notechis scutatus scutatus]]
[[Category: Notechis scutatus scutatus]]
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[[Category: Eaker, D]]
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[[Category: Eaker D]]
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[[Category: Eklund, H]]
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[[Category: Eklund H]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund P]]
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[[Category: Uhlin, U]]
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[[Category: Uhlin U]]
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[[Category: Westerlund, B]]
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[[Category: Westerlund B]]
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[[Category: Hydrolase]]
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[[Category: Lipid degradation]]
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[[Category: Phospholipase a2]]
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[[Category: Presynaptic neurotoxin]]
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[[Category: Venom]]
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Current revision

NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2

PDB ID 1ae7

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