4cg9

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==Human choline kinase a1 in complex with compound 12==
==Human choline kinase a1 in complex with compound 12==
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<StructureSection load='4cg9' size='340' side='right' caption='[[4cg9]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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<StructureSection load='4cg9' size='340' side='right'caption='[[4cg9]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CG9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CG9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GQG:N,N-DIMETHYL-1-[(4-PHENYLPHENYL)METHYL]PYRIDIN-1-IUM-4-AMINE'>GQG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cg8|4cg8]], [[4cga|4cga]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GQG:N,N-DIMETHYL-1-[(4-PHENYLPHENYL)METHYL]PYRIDIN-1-IUM-4-AMINE'>GQG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cg9 OCA], [http://pdbe.org/4cg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4cg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cg9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cg9 OCA], [https://pdbe.org/4cg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cg9 RCSB], [https://www.ebi.ac.uk/pdbsum/4cg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cg9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
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[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4cg9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4cg9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Choline kinase 3D structures|Choline kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Capitan-Canadas, F]]
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[[Category: Large Structures]]
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[[Category: Carrasco, M P]]
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[[Category: Capitan-Canadas F]]
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[[Category: Concepcion, C]]
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[[Category: Carrasco MP]]
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[[Category: Conejo-Garcia, A]]
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[[Category: Concepcion C]]
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[[Category: Entrena-Guadix, A]]
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[[Category: Conejo-Garcia A]]
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[[Category: Espinosa, A]]
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[[Category: Entrena-Guadix A]]
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[[Category: Figuerola-Conchas, A]]
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[[Category: Espinosa A]]
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[[Category: Gallo, M A]]
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[[Category: Figuerola-Conchas A]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Gallo MA]]
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[[Category: Marco, C]]
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[[Category: Hurtado-Guerrero R]]
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[[Category: Ramos-Torrecillas, J]]
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[[Category: Marco C]]
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[[Category: Rios-Marco, P]]
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[[Category: Ramos-Torrecillas J]]
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[[Category: Rubio-Ruiz, B]]
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[[Category: Rios-Marco P]]
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[[Category: Biscationic compound]]
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[[Category: Rubio-Ruiz B]]
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[[Category: Cancer]]
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[[Category: Drug target]]
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[[Category: Transferase]]
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Current revision

Human choline kinase a1 in complex with compound 12

PDB ID 4cg9

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