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4wls

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==Crystal structure of the metal-free (repressor) form of E. Coli CUER, a copper efflux regulator, bound to COPA promoter DNA==
==Crystal structure of the metal-free (repressor) form of E. Coli CUER, a copper efflux regulator, bound to COPA promoter DNA==
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<StructureSection load='4wls' size='340' side='right' caption='[[4wls]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4wls' size='340' side='right'caption='[[4wls]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wls]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_dh5[alpha] Escherichia coli dh5[alpha]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WLS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wls]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_DH5alpha Escherichia coli DH5alpha] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WLS FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.105&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wlw|4wlw]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cueR, ybbI, b0487, JW0476 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=668369 Escherichia coli DH5[alpha]])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wls OCA], [https://pdbe.org/4wls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wls RCSB], [https://www.ebi.ac.uk/pdbsum/4wls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wls ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wls OCA], [http://pdbe.org/4wls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wls RCSB], [http://www.ebi.ac.uk/pdbsum/4wls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wls ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CUER_ECOLI CUER_ECOLI]] Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations.<ref>PMID:10915804</ref> <ref>PMID:11399769</ref>
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[https://www.uniprot.org/uniprot/CUER_ECOLI CUER_ECOLI] Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations.<ref>PMID:10915804</ref> <ref>PMID:11399769</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4wls" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4wls" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Canalizo-Hernandez, M]]
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[[Category: Large Structures]]
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[[Category: Halloran, T V.O]]
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[[Category: Synthetic construct]]
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[[Category: Mondragon, A]]
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[[Category: Canalizo-Hernandez M]]
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[[Category: Philips, S J]]
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[[Category: Mondragon A]]
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[[Category: Merr-family transcription regulator]]
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[[Category: O'Halloran TV]]
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[[Category: Metal-free form]]
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[[Category: Philips SJ]]
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[[Category: Protein-dna complex]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulator-dna complex]]
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Current revision

Crystal structure of the metal-free (repressor) form of E. Coli CUER, a copper efflux regulator, bound to COPA promoter DNA

PDB ID 4wls

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