4x2q

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==Crystal Structure of Human Aldehyde Dehydrogenase, ALDH1a2==
==Crystal Structure of Human Aldehyde Dehydrogenase, ALDH1a2==
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<StructureSection load='4x2q' size='340' side='right' caption='[[4x2q]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
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<StructureSection load='4x2q' size='340' side='right'caption='[[4x2q]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X2Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X2Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALDH1A2, RALDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x2q OCA], [https://pdbe.org/4x2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x2q RCSB], [https://www.ebi.ac.uk/pdbsum/4x2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x2q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x2q OCA], [http://pdbe.org/4x2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x2q RCSB], [http://www.ebi.ac.uk/pdbsum/4x2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x2q ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AL1A2_HUMAN AL1A2_HUMAN]] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
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[https://www.uniprot.org/uniprot/AL1A2_HUMAN AL1A2_HUMAN] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
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==See Also==
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Retinal dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Amory, J K]]
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[[Category: Amory JK]]
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[[Category: Goldstein, A S]]
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[[Category: Goldstein AS]]
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[[Category: Paik, J]]
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[[Category: Le Trong I]]
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[[Category: Stenkamp, R E]]
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[[Category: Paik J]]
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[[Category: Trong, I Le]]
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[[Category: Stenkamp RE]]
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[[Category: Dehydrogenase]]
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[[Category: Isozyme]]
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[[Category: Oxidoreductase]]
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[[Category: Spermatogenesis]]
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[[Category: Testis]]
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Current revision

Crystal Structure of Human Aldehyde Dehydrogenase, ALDH1a2

PDB ID 4x2q

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