5ke9

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==mouse Klf4 E446P ZnF1-3 and TpG/CpA sequence DNA complex structure==
==mouse Klf4 E446P ZnF1-3 and TpG/CpA sequence DNA complex structure==
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<StructureSection load='5ke9' size='340' side='right' caption='[[5ke9]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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<StructureSection load='5ke9' size='340' side='right'caption='[[5ke9]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ke9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KE9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ke9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KE9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.336&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ke6|5ke6]], [[5ke7|5ke7]], [[5ke8|5ke8]], [[5kea|5kea]], [[5keb|5keb]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Klf4, Ezf, Gklf, Zie ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ke9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke9 OCA], [https://pdbe.org/5ke9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ke9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ke9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ke9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke9 OCA], [http://pdbe.org/5ke9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ke9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ke9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLF4_MOUSE KLF4_MOUSE]] Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).<ref>PMID:10556311</ref> <ref>PMID:10431239</ref> <ref>PMID:15358627</ref> <ref>PMID:16954384</ref> <ref>PMID:17060454</ref> <ref>PMID:19816951</ref> <ref>PMID:20071344</ref>
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[https://www.uniprot.org/uniprot/KLF4_MOUSE KLF4_MOUSE] Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).<ref>PMID:10556311</ref> <ref>PMID:10431239</ref> <ref>PMID:15358627</ref> <ref>PMID:16954384</ref> <ref>PMID:17060454</ref> <ref>PMID:19816951</ref> <ref>PMID:20071344</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Cheng, X]]
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[[Category: Mus musculus]]
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[[Category: Hashimoto, H]]
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[[Category: Synthetic construct]]
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[[Category: Klf4]]
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[[Category: Cheng X]]
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[[Category: Kruppel-like factor]]
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[[Category: Hashimoto H]]
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[[Category: Transcription factor-dna complex]]
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[[Category: Zinc finger]]
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Current revision

mouse Klf4 E446P ZnF1-3 and TpG/CpA sequence DNA complex structure

PDB ID 5ke9

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