5tod

<StructureSection load='5tod' size='340' side='right' caption='[[5tod]], [[Resolution|resolution]] 2.96&Aring;' scene=''>

<table><tr><td colspan='2'>[[5tod]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TOD FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C2CD2L, KIAA0285, TMEM24, DLNB23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tod OCA], [http://pdbe.org/5tod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tod RCSB], [http://www.ebi.ac.uk/pdbsum/5tod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tod ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Insulin is released by beta cells in pulses regulated by calcium and phosphoinositide signaling. Here, we describe how transmembrane protein 24 (TMEM24) helps coordinate these signaling events. We showed that TMEM24 is an endoplasmic reticulum (ER)-anchored membrane protein whose reversible localization to ER-plasma membrane (PM) contacts is governed by phosphorylation and dephosphorylation in response to oscillations in cytosolic calcium. A lipid-binding module in TMEM24 transports the phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] precursor phosphatidylinositol between bilayers, allowing replenishment of PI(4,5)P2 hydrolyzed during signaling. In the absence of TMEM24, calcium oscillations are abolished, leading to a defect in triggered insulin release. Our findings implicate direct lipid transport between the ER and the PM in the control of insulin secretion, a process impaired in patients with type II diabetes.

 

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.,Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171. PMID:28209843<ref>PMID:28209843</ref>

 

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 5tod" style="background-color:#fffaf0;"></div>

[[Category: Human]]

[[Category: Lees, J A]]

[[Category: Reinisch, K M]]

[[Category: Lipid transfer protein]]

[[Category: Smp]]