5u1w

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==Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120==
==Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120==
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<StructureSection load='5u1w' size='340' side='right' caption='[[5u1w]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='5u1w' size='340' side='right'caption='[[5u1w]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5u1w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ailme Ailme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U1W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5u1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ailuropoda_melanoleuca Ailuropoda melanoleuca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U1W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7RY:N-[2-({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)QUINOLIN-5-YL]-2-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DECAN-1-YL]ACETAMIDE'>7RY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.501&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u1l|5u1l]], [[5u1u|5u1u]], [[5u1v|5u1v]], [[5u1x|5u1x]], [[5u1y|5u1y]], [[5u2h|5u2h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RY:N-[2-({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)QUINOLIN-5-YL]-2-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DECAN-1-YL]ACETAMIDE'>7RY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P2RX7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9646 AILME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u1w OCA], [https://pdbe.org/5u1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u1w RCSB], [https://www.ebi.ac.uk/pdbsum/5u1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u1w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u1w OCA], [http://pdbe.org/5u1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u1w RCSB], [http://www.ebi.ac.uk/pdbsum/5u1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u1w ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/G1M6C4_AILME G1M6C4_AILME]] Receptor for ATP that acts as a ligand-gated ion channel.[RuleBase:RU000681]
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[https://www.uniprot.org/uniprot/G1M6C4_AILME G1M6C4_AILME] Receptor for ATP that acts as a ligand-gated ion channel.[RuleBase:RU000681]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5u1w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5u1w" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ailme]]
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[[Category: Ailuropoda melanoleuca]]
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[[Category: Karasawa, A]]
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[[Category: Large Structures]]
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[[Category: Kawate, T]]
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[[Category: Karasawa A]]
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[[Category: Membrane protein]]
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[[Category: Kawate T]]
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[[Category: Membrane protein: atp-gated ion channel: allosteric antagonist bound: closed state]]
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Current revision

Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120

PDB ID 5u1w

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