1u4e

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==Crystal Structure of Cytoplasmic Domains of GIRK1 channel==
==Crystal Structure of Cytoplasmic Domains of GIRK1 channel==
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<StructureSection load='1u4e' size='340' side='right' caption='[[1u4e]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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<StructureSection load='1u4e' size='340' side='right'caption='[[1u4e]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U4E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U4E FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p7b|1p7b]], [[1n9p|1n9p]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnj3, GIRK1, Kga ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4e OCA], [https://pdbe.org/1u4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u4e RCSB], [https://www.ebi.ac.uk/pdbsum/1u4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u4e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4e OCA], [http://pdbe.org/1u4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u4e RCSB], [http://www.ebi.ac.uk/pdbsum/1u4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u4e ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IRK3_MOUSE IRK3_MOUSE]] This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
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[https://www.uniprot.org/uniprot/KCNJ3_MOUSE KCNJ3_MOUSE] This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u4/1u4e_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u4/1u4e_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1u4e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1u4e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Arrabit, C]]
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[[Category: Mus musculus]]
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[[Category: Choe, S]]
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[[Category: Arrabit C]]
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[[Category: Kwiatkowski, W]]
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[[Category: Choe S]]
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[[Category: Pegan, S]]
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[[Category: Kwiatkowski W]]
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[[Category: Slesinger, P A]]
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[[Category: Pegan S]]
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[[Category: Zhou, W]]
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[[Category: Slesinger PA]]
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[[Category: Metal transport]]
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[[Category: Zhou W]]

Current revision

Crystal Structure of Cytoplasmic Domains of GIRK1 channel

PDB ID 1u4e

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