2z80

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==Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide==
==Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide==
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<StructureSection load='2z80' size='340' side='right' caption='[[2z80]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='2z80' size='340' side='right'caption='[[2z80]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2z80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z80 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2z80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z80 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2z7x|2z7x]], [[2z81|2z81]], [[2z82|2z82]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLR2, TIL4, VLRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z80 OCA], [https://pdbe.org/2z80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z80 RCSB], [https://www.ebi.ac.uk/pdbsum/2z80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z80 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z80 OCA], [http://pdbe.org/2z80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z80 RCSB], [http://www.ebi.ac.uk/pdbsum/2z80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z80 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN]] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
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[https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/2z80_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/2z80_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 2z80" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2z80" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Eptatretus burgeri]]
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[[Category: Heo, J Y]]
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[[Category: Homo sapiens]]
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[[Category: Jin, M S]]
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[[Category: Large Structures]]
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[[Category: Kim, S E]]
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[[Category: Heo JY]]
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[[Category: Lee, J O]]
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[[Category: Jin MS]]
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[[Category: Glycoprotein]]
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[[Category: Kim SE]]
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[[Category: Immune response]]
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[[Category: Lee JO]]
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[[Category: Immune system]]
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[[Category: Inflammatory response]]
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[[Category: Innate immunity]]
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[[Category: Leucine-rich repeat]]
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[[Category: Lipopeptide]]
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[[Category: Membrane]]
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[[Category: Receptor]]
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[[Category: Tlr2]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

PDB ID 2z80

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