5jyy

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==Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses==
==Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses==
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<StructureSection load='5jyy' size='340' side='right' caption='[[5jyy]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5jyy' size='340' side='right'caption='[[5jyy]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jyy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5e6l 5e6l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5e6l 5e6l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PY:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-[(2-METHOXYETHYL)CARBAMOYL]-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>6PY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mwx|4mwx]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PY:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-[(2-METHOXYETHYL)CARBAMOYL]-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>6PY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 9INFA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyy OCA], [https://pdbe.org/5jyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyy RCSB], [https://www.ebi.ac.uk/pdbsum/5jyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyy ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyy OCA], [http://pdbe.org/5jyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyy RCSB], [http://www.ebi.ac.uk/pdbsum/5jyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/R4NFR6_9INFA R4NFR6_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
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[https://www.uniprot.org/uniprot/R4NFR6_9INFA R4NFR6_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jyy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jyy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Influenza A virus]]
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[[Category: Bi, Y]]
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[[Category: Large Structures]]
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[[Category: Fu, L]]
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[[Category: Bi Y]]
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[[Category: Gao, G F]]
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[[Category: Fu L]]
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[[Category: Li, X]]
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[[Category: Gao GF]]
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[[Category: Li, Y]]
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[[Category: Li X]]
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[[Category: Lu, X]]
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[[Category: Li Y]]
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[[Category: Lv, X]]
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[[Category: Lu X]]
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[[Category: Qi, J]]
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[[Category: Lv X]]
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[[Category: Wu, Y]]
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[[Category: Qi J]]
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[[Category: Yan, J]]
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[[Category: Wu Y]]
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[[Category: Zhang, S]]
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[[Category: Yan J]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Zhang S]]
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[[Category: Neuraminidase inhibitor]]
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[[Category: Tetravalent zanamivir]]
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Current revision

Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses

PDB ID 5jyy

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