2rh1

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==High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.==
==High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.==
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<StructureSection load='2rh1' size='340' side='right' caption='[[2rh1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2rh1' size='340' side='right'caption='[[2rh1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2rh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The April 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RH1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2rh1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RH1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR / E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rh1 OCA], [http://pdbe.org/2rh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2rh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rh1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rh1 OCA], [https://pdbe.org/2rh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2rh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rh1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
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[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/2rh1_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/2rh1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Beta-2 Adrenergic Receptor|Beta-2 Adrenergic Receptor]]
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*[[Adrenergic receptor|Adrenergic receptor]]
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*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
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*[[G protein-coupled receptor|G protein-coupled receptor]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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*[[Nobel Prizes for 3D Molecular Structure|Nobel Prizes for 3D Molecular Structure]]
 
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*[[Suggestions for new articles|Suggestions for new articles]]
 
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*[[User:Wayne Decatur/NASCE2011|User:Wayne Decatur/NASCE2011]]
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Adrenergic Receptors]]
[[Category: Adrenergic Receptors]]
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[[Category: Human]]
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[[Category: Escherichia virus T4]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
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[[Category: Cherezov V]]
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[[Category: Cherezov, V]]
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[[Category: Choi HJ]]
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[[Category: Choi, H J]]
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[[Category: Hanson MA]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Kobilka BK]]
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[[Category: Hanson, M A]]
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[[Category: Kobilka TS]]
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[[Category: Kobilka, B K]]
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[[Category: Kuhn P]]
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[[Category: Kobilka, T S]]
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[[Category: Rasmussen SGF]]
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[[Category: Kuhn, P]]
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[[Category: Rosenbaum DM]]
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[[Category: Rasmussen, S G.F]]
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[[Category: Stevens RC]]
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[[Category: Rosenbaum, D M]]
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[[Category: Thian FS]]
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[[Category: Stevens, R C]]
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[[Category: Weis WI]]
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[[Category: Thian, F S]]
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[[Category: Weis, W I]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Adrenergic]]
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[[Category: Atcg3d]]
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[[Category: Cholesterol]]
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[[Category: Fusion]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Lipidic]]
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[[Category: Lipidic cubic phase]]
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[[Category: Membrane protein]]
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[[Category: Membrane protein - hydrolase complex]]
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[[Category: Mesophase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Structural genomic]]
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Current revision

High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.

PDB ID 2rh1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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