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5wbe

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==COX-1:MOFEZOLAC COMPLEX STRUCTURE==
==COX-1:MOFEZOLAC COMPLEX STRUCTURE==
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<StructureSection load='5wbe' size='340' side='right' caption='[[5wbe]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='5wbe' size='340' side='right'caption='[[5wbe]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wbe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_ammon_aries Ovis ammon aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WBE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WBE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wbe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WBE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63X:Mofezolac'>63X</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u6x|5u6x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=63X:Mofezolac'>63X</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTGS1, COX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9940 Ovis ammon aries])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wbe OCA], [https://pdbe.org/5wbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wbe RCSB], [https://www.ebi.ac.uk/pdbsum/5wbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wbe ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wbe OCA], [http://pdbe.org/5wbe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wbe RCSB], [http://www.ebi.ac.uk/pdbsum/5wbe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wbe ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PGH1_SHEEP PGH1_SHEEP]] May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
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[https://www.uniprot.org/uniprot/PGH1_SHEEP PGH1_SHEEP] May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wbe" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wbe" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ovis ammon aries]]
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[[Category: Large Structures]]
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Ovis aries]]
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[[Category: Cingolani, G]]
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[[Category: Cingolani G]]
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[[Category: Panella, A]]
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[[Category: Panella A]]
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[[Category: Perrone, M G]]
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[[Category: Perrone MG]]
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[[Category: Scilimati, A]]
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[[Category: Scilimati A]]
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[[Category: Smith, W L]]
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[[Category: Smith WL]]
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[[Category: Vitale, P]]
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[[Category: Vitale P]]
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[[Category: Cox-1]]
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[[Category: Cyclooxygenase]]
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[[Category: Heme]]
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[[Category: Mofezolac]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Peroxidase]]
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[[Category: Prostaglandin]]
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Current revision

COX-1:MOFEZOLAC COMPLEX STRUCTURE

PDB ID 5wbe

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