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5kvp

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==Solution structure of the catalytic domain of zoocin A==
==Solution structure of the catalytic domain of zoocin A==
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<StructureSection load='5kvp' size='340' side='right' caption='[[5kvp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='5kvp' size='340' side='right'caption='[[5kvp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kvp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"animal_pyogenes,_type_a"_edwards_1934 "animal pyogenes, type a" edwards 1934]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KVP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kvp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_equi_subsp._zooepidemicus Streptococcus equi subsp. zooepidemicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KVP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">zooA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40041 "Animal pyogenes, type A" Edwards 1934])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kvp OCA], [http://pdbe.org/5kvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kvp RCSB], [http://www.ebi.ac.uk/pdbsum/5kvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kvp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kvp OCA], [https://pdbe.org/5kvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kvp RCSB], [https://www.ebi.ac.uk/pdbsum/5kvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kvp ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O54308_STRSZ O54308_STRSZ]
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Zoocin A is a Zn-metallopeptidase secreted by Streptococcus zooepidemicus strain 4881. Its catalytic domain is responsible for cleaving the D-alanyl-L-alanine peptide bond in streptococcal peptidoglycan. The solution NMR structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain (rCAT C74A) has been determined. With a previous structure determination for the recombinant target recognition domain (rTRD), this completes the 3D structure of zoocin A. While the structure of rCAT C74A resembles those of the catalytic domains of lysostaphin and LytM, the substrate binding groove is wider and no tyrosine residue was observed in the active site. Proteins 2016. (c) 2016 Wiley Periodicals, Inc.
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Solution structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain of Zoocin A.,Xing M, Simmonds RS, Timkovich R Proteins. 2016 Oct 3. doi: 10.1002/prot.25178. PMID:27699884<ref>PMID:27699884</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5kvp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Animal pyogenes, type a edwards 1934]]
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[[Category: Large Structures]]
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[[Category: Simmonds, R S]]
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[[Category: Streptococcus equi subsp. zooepidemicus]]
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[[Category: Timkovich, R]]
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[[Category: Simmonds RS]]
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[[Category: Xing, M]]
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[[Category: Timkovich R]]
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[[Category: Anti-microbial]]
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[[Category: Xing M]]
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[[Category: Endopeptidase]]
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[[Category: Exoenzyme]]
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[[Category: Hydrolase]]
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Current revision

Solution structure of the catalytic domain of zoocin A

PDB ID 5kvp

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