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4cme

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==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
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<StructureSection load='4cme' size='340' side='right' caption='[[4cme]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='4cme' size='340' side='right'caption='[[4cme]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CME FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CME FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KTZ:N4,N4-DIMETHYL-5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>KTZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=KTZ:N4,N4-DIMETHYL-5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>KTZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cl8|4cl8]], [[4cld|4cld]], [[4cle|4cle]], [[4clh|4clh]], [[4clo|4clo]], [[4clr|4clr]], [[4clx|4clx]], [[4cm1|4cm1]], [[4cm3|4cm3]], [[4cm4|4cm4]], [[4cm5|4cm5]], [[4cm6|4cm6]], [[4cm7|4cm7]], [[4cm8|4cm8]], [[4cm9|4cm9]], [[4cma|4cma]], [[4cmb|4cmb]], [[4cmc|4cmc]], [[4cmg|4cmg]], [[4cmi|4cmi]], [[4cmj|4cmj]], [[4cmk|4cmk]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cme OCA], [https://pdbe.org/4cme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cme RCSB], [https://www.ebi.ac.uk/pdbsum/4cme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cme ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cme OCA], [http://pdbe.org/4cme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cme RCSB], [http://www.ebi.ac.uk/pdbsum/4cme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cme ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4cme" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4cme" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Pteridine reductase|Pteridine reductase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pteridine reductase]]
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[[Category: Large Structures]]
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[[Category: Trybb]]
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[[Category: Trypanosoma brucei brucei]]
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[[Category: Barrack, K L]]
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[[Category: Barrack KL]]
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[[Category: Hunter, W N]]
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[[Category: Hunter WN]]
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[[Category: Oxidoreductase]]
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[[Category: Ptr1]]
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[[Category: Short-chain dehydrogenase/reductase]]
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Current revision

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor

PDB ID 4cme

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