3sn6

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==Crystal structure of the beta2 adrenergic receptor-Gs protein complex==
==Crystal structure of the beta2 adrenergic receptor-Gs protein complex==
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<StructureSection load='3sn6' size='340' side='right' caption='[[3sn6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='3sn6' size='340' side='right'caption='[[3sn6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sn6]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SN6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sn6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn6 OCA], [http://pdbe.org/3sn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sn6 RCSB], [http://www.ebi.ac.uk/pdbsum/3sn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn6 OCA], [https://pdbe.org/3sn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn6 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4]] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [[http://www.uniprot.org/uniprot/GNAS2_BOVIN GNAS2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_RAT GBB1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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[https://www.uniprot.org/uniprot/GNAS2_BOVIN GNAS2_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Beta-2 Adrenergic Receptor|Beta-2 Adrenergic Receptor]]
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*[[Adrenergic receptor|Adrenergic receptor]]
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*[[Beta2 adrenergic receptor-Gs protein complex|Beta2 adrenergic receptor-Gs protein complex]]
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*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[G protein-coupled receptor|G protein-coupled receptor]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Hormone|Hormone]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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*[[Nobel Prizes for 3D Molecular Structure|Nobel Prizes for 3D Molecular Structure]]
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*[[Neurotransmitters|Neurotransmitters]]
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*[[Suggestions for new articles|Suggestions for new articles]]
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*[[Transducin 3D structures|Transducin 3D structures]]
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*[[Transducin|Transducin]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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*[[User:Wayne Decatur/UNH BCHEM833 Structural Analysis Workshop Session Fall 2012|User:Wayne Decatur/UNH BCHEM833 Structural Analysis Workshop Session Fall 2012]]
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*[[User:Wayne Decatur/UNH BCHEM833 Structural Proteomics Introductory Lecture Fall 2012|User:Wayne Decatur/UNH BCHEM833 Structural Proteomics Introductory Lecture Fall 2012]]
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*[[3D structures of antibody|3D structures of antibody]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lysozyme]]
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[[Category: Bos taurus]]
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[[Category: Caffrey, M]]
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[[Category: Escherichia virus T4]]
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[[Category: Calinski, D]]
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[[Category: Homo sapiens]]
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[[Category: Chae, P S]]
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[[Category: Lama glama]]
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[[Category: Chung, K Y]]
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[[Category: Large Structures]]
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[[Category: DeVree, B T]]
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[[Category: Rattus norvegicus]]
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[[Category: Gellman, S H]]
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[[Category: Caffrey M]]
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[[Category: Kobilka, B K]]
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[[Category: Calinski D]]
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[[Category: Kobilka, T S]]
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[[Category: Chae PS]]
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[[Category: Kruse, A C]]
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[[Category: Chung KY]]
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[[Category: Lyons, J A]]
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[[Category: DeVree BT]]
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[[Category: Mathiesen, J M]]
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[[Category: Gellman SH]]
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[[Category: Pardon, E]]
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[[Category: Kobilka BK]]
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[[Category: Rasmussen, S G.F]]
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[[Category: Kobilka TS]]
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[[Category: Shah, S T.A]]
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[[Category: Kruse AC]]
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[[Category: Skiniotis, G]]
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[[Category: Lyons JA]]
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[[Category: Steyaert, J]]
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[[Category: Mathiesen JM]]
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[[Category: Sunahara, R K]]
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[[Category: Pardon E]]
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[[Category: Thian, F S]]
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[[Category: Rasmussen SGF]]
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[[Category: Weis, W I]]
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[[Category: Shah STA]]
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[[Category: Zou, Y]]
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[[Category: Skiniotis G]]
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[[Category: G protein signaling]]
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[[Category: Steyaert J]]
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[[Category: G protein-coupled receptor]]
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[[Category: Sunahara RK]]
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[[Category: Gpcr]]
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[[Category: Thian FS]]
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[[Category: Nanobody]]
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[[Category: Weis WI]]
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[[Category: Seven transmembrane receptor]]
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[[Category: Zou Y]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein-hydrolase complex]]
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Current revision

Crystal structure of the beta2 adrenergic receptor-Gs protein complex

PDB ID 3sn6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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