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5jq1

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Current revision (19:01, 20 September 2023) (edit) (undo)
 
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==Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic==
==Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic==
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<StructureSection load='5jq1' size='340' side='right' caption='[[5jq1]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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<StructureSection load='5jq1' size='340' side='right'caption='[[5jq1]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jq1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jq1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JQ1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZPF:N-[(1S,2R,3R,4R,5S)-2,3-dihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-4-yl]acetamide'>ZPF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jpv|5jpv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZPF:N-[(1S,2R,3R,4R,5S)-2,3-dihydroxy-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octan-4-yl]acetamide'>ZPF</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASGR1, CLEC4H1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jq1 OCA], [https://pdbe.org/5jq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jq1 RCSB], [https://www.ebi.ac.uk/pdbsum/5jq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jq1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jq1 OCA], [http://pdbe.org/5jq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jq1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jq1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ASGR1_HUMAN ASGR1_HUMAN]] Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
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[https://www.uniprot.org/uniprot/ASGR1_HUMAN ASGR1_HUMAN] Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Liu, S]]
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[[Category: Large Structures]]
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[[Category: Asialoglycoprotein receptor]]
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[[Category: Liu S]]
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[[Category: Carbohydrate]]
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[[Category: Liver targeting]]
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[[Category: Sugar binding protein]]
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Current revision

Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic

PDB ID 5jq1

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