2b35

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:15, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2b35.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan==
-
|PDB= 2b35 |SIZE=350|CAPTION= <scene name='initialview01'>2b35</scene>, resolution 2.300&Aring;
+
<StructureSection load='2b35' size='340' side='right'caption='[[2b35]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene>
+
<table><tr><td colspan='2'>[[2b35]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B35 FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
|GENE= inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b35 OCA], [https://pdbe.org/2b35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b35 RCSB], [https://www.ebi.ac.uk/pdbsum/2b35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b35 ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1bvr|1BVR]], [[1enz|1ENZ]], [[1eny|1ENY]], [[1zid|1ZID]], [[1p44|1P44]], [[1p45|1P45]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b35 OCA], [http://www.ebi.ac.uk/pdbsum/2b35 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b35 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b35_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b35 ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan'''
+
==See Also==
-
 
+
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2B35 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA].
+
[[Category: Large Structures]]
-
[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
+
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Single protein]]
+
[[Category: Amin A]]
-
[[Category: Amin, A.]]
+
[[Category: Boyne MS]]
-
[[Category: Boyne, M S.]]
+
[[Category: Johnson F]]
-
[[Category: Johnson, F.]]
+
[[Category: Kaur T]]
-
[[Category: Kaur, T.]]
+
[[Category: Novichenok P]]
-
[[Category: Novichenok, P.]]
+
[[Category: Stratton C]]
-
[[Category: Stratton, C.]]
+
[[Category: Sullivan TJ]]
-
[[Category: Sullivan, T J.]]
+
[[Category: Truglio JJ]]
-
[[Category: Truglio, J J.]]
+
[[Category: Zhang X]]
-
[[Category: Zhang, X.]]
+
-
[[Category: enoyl reductase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:00:46 2008''
+

Current revision

Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan

PDB ID 2b35

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b35"
Personal tools