5hpw

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==Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: Binding studies and structure determination==
==Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: Binding studies and structure determination==
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<StructureSection load='5hpw' size='340' side='right' caption='[[5hpw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5hpw' size='340' side='right'caption='[[5hpw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hpw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HPW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hpw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HPW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3CJ:6-PROPYL-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE'>3CJ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ff1|5ff1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3CJ:6-PROPYL-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE'>3CJ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpw OCA], [http://pdbe.org/5hpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hpw RCSB], [http://www.ebi.ac.uk/pdbsum/5hpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpw OCA], [https://pdbe.org/5hpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hpw RCSB], [https://www.ebi.ac.uk/pdbsum/5hpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpw ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
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==See Also==
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*[[Lactoperoxidase|Lactoperoxidase]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Capra hircus]]
[[Category: Capra hircus]]
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[[Category: Kaur, P]]
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[[Category: Large Structures]]
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[[Category: Sharma, P]]
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[[Category: Kaur P]]
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[[Category: Sharma, S]]
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[[Category: Sharma P]]
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[[Category: Singh, A]]
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[[Category: Sharma S]]
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[[Category: Singh, R P]]
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[[Category: Singh A]]
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[[Category: Singh, T P]]
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[[Category: Singh RP]]
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[[Category: Oxidoreductase]]
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[[Category: Singh TP]]

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Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: Binding studies and structure determination

PDB ID 5hpw

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