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5cxt

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==Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Unknown at 2.20 A resolution==
==Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Unknown at 2.20 A resolution==
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<StructureSection load='5cxt' size='340' side='right' caption='[[5cxt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5cxt' size='340' side='right'caption='[[5cxt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cxt]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CXT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cxt]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CXT FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rbm39, Caper, Rnpc2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), U2af2, U2af65 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxt OCA], [http://pdbe.org/5cxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cxt RCSB], [http://www.ebi.ac.uk/pdbsum/5cxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cxt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxt OCA], [https://pdbe.org/5cxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cxt RCSB], [https://www.ebi.ac.uk/pdbsum/5cxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cxt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RBM39_MOUSE RBM39_MOUSE]] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre-mRNA splicing process.<ref>PMID:11704680</ref> [[http://www.uniprot.org/uniprot/U2AF2_MOUSE U2AF2_MOUSE]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 (By similarity).
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[https://www.uniprot.org/uniprot/RBM39_MOUSE RBM39_MOUSE] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre-mRNA splicing process.<ref>PMID:11704680</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Mus musculus]]
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[[Category: TCELL, Partnership for T-Cell Biology]]
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[[Category: Jcsg]]
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[[Category: Partnership for t-cell biology]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Rna binding protein]]
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[[Category: Tcell]]
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Current revision

Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Unknown at 2.20 A resolution

PDB ID 5cxt

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