5f2u

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==Structure of Fully modified farnesylated INPP5E Peptide in complex with PDE6D==
==Structure of Fully modified farnesylated INPP5E Peptide in complex with PDE6D==
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<StructureSection load='5f2u' size='340' side='right' caption='[[5f2u]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='5f2u' size='340' side='right'caption='[[5f2u]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5f2u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F2U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5f2u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F2U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=FAR:FARNESYL'>FAR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE6D, PDED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=FAR:FARNESYL'>FAR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f2u OCA], [http://pdbe.org/5f2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f2u RCSB], [http://www.ebi.ac.uk/pdbsum/5f2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f2u ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f2u OCA], [https://pdbe.org/5f2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f2u RCSB], [https://www.ebi.ac.uk/pdbsum/5f2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f2u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
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[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5f2u" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5f2u" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Fansa, E K]]
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[[Category: Large Structures]]
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[[Category: Isamil, S]]
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[[Category: Fansa EK]]
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[[Category: Wittinghofer, A]]
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[[Category: Isamil S]]
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[[Category: Immunoglobulin-like]]
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[[Category: Wittinghofer A]]
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[[Category: Lipid binding protein]]
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[[Category: Signaling protein]]
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Current revision

Structure of Fully modified farnesylated INPP5E Peptide in complex with PDE6D

PDB ID 5f2u

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