2b6b

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[[Image:2b6b.gif|left|200px]]
 
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{{Structure
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==Cryo EM structure of Dengue complexed with CRD of DC-SIGN==
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|PDB= 2b6b |SIZE=350|CAPTION= <scene name='initialview01'>2b6b</scene>
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<SX load='2b6b' size='340' side='right' viewer='molstar' caption='[[2b6b]], [[Resolution|resolution]] 25.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2b6b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B6B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 25&#8491;</td></tr>
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|GENE= CD209 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6b OCA], [https://pdbe.org/2b6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6b RCSB], [https://www.ebi.ac.uk/pdbsum/2b6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6b ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6b OCA], [http://www.ebi.ac.uk/pdbsum/2b6b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b6b RCSB]</span>
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[https://www.uniprot.org/uniprot/Q9WDA7_9FLAV Q9WDA7_9FLAV] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Cryo EM structure of Dengue complexed with CRD of DC-SIGN'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b6b_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Dengue virus (DENV) is a significant human pathogen that causes millions of infections and results in about 24,000 deaths each year. Dendritic cell-specific ICAM3 grabbing nonintegrin (DC-SIGN), abundant in immature dendritic cells, was previously reported as being an ancillary receptor interacting with the surface of DENV. The structure of DENV in complex with the carbohydrate recognition domain (CRD) of DC-SIGN was determined by cryo-electron microscopy at 25 A resolution. One CRD monomer was found to bind to two glycosylation sites at Asn67 of two neighboring glycoproteins in each icosahedral asymmetric unit, leaving the third Asn67 residue vacant. The vacancy at the third Asn67 site is a result of the nonequivalence of the glycoprotein environments, leaving space for the primary receptor binding to domain III of E. The use of carbohydrate moieties for receptor binding sites suggests a mechanism for avoiding immune surveillance.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b6b ConSurf].
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2B6B is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6B OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</SX>
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Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN., Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG, Cell. 2006 Feb 10;124(3):485-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16469696 16469696]
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[[Category: Dengue virus]]
[[Category: Dengue virus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bator-Kelly, C M.]]
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[[Category: Bator-Kelly CM]]
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[[Category: Battisti, A J.]]
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[[Category: Battisti AJ]]
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[[Category: Chipman, P R.]]
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[[Category: Chipman PR]]
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[[Category: Gregorio, G.]]
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[[Category: Gregorio G]]
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[[Category: Hendrickson, W A.]]
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[[Category: Hendrickson WA]]
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[[Category: Kuhn, R J.]]
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[[Category: Kuhn RJ]]
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[[Category: Pokidysheva, E.]]
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[[Category: Pokidysheva E]]
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[[Category: Rossmann, M G.]]
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[[Category: Rossmann MG]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: cryo em dengue crd dc-sign]]
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[[Category: icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:02:04 2008''
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Current revision

Cryo EM structure of Dengue complexed with CRD of DC-SIGN

2b6b, resolution 25.00Å

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OCA

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