5ay2

<StructureSection load='5ay2' size='340' side='right' caption='[[5ay2]], [[Resolution|resolution]] 1.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[5ay2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AY2 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ay3|5ay3]], [[5ay4|5ay4]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ay2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay2 OCA], [http://pdbe.org/5ay2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ay2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ay2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay2 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Metallo-base pairs have been extensively studied for applications in nucleic acid-based nanodevices and genetic code expansion. Metallo-base pairs composed of natural nucleobases are attractive because nanodevices containing natural metallo-base pairs can be easily prepared from commercially available sources. Previously, we have reported a crystal structure of a DNA duplex containing THgII T base pairs. Herein, we have determined a high-resolution crystal structure of the second natural metallo-base pair between pyrimidine bases CAgI C formed in an RNA duplex. One AgI occupies the center between two cytosines and forms a CAgI C base pair through N3AgI N3 linear coordination. The CAgI C base pair formation does not disturb the standard A-form conformation of RNA. Since the CAgI C base pair is structurally similar to the canonical Watson-Crick base pairs, it can be a useful building block for structure-based design and fabrication of nucleic acid-based nanodevices.

High-Resolution Crystal Structure of Silver(I)-RNA Hybrid Duplex Containing Watson-Crick-like CSilver(I)C Metallo-Base Pairs.,Kondo J, Tada Y, Dairaku T, Saneyoshi H, Okamoto I, Tanaka Y, Ono A Angew Chem Int Ed Engl. 2015 Oct 8. doi: 10.1002/anie.201507894. PMID:26448329<ref>PMID:26448329</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 5ay2" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Dairaku, T]]

[[Category: Kondo, J]]

[[Category: Okamoto, I]]

[[Category: Ono, A]]

[[Category: Saneyoshi, H]]

[[Category: Tada, Y]]

[[Category: Tanaka, Y]]

[[Category: Metallo base pair]]

[[Category: Rna]]