4zre

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==Crystal structure of SMG1 F278D mutant==
==Crystal structure of SMG1 F278D mutant==
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<StructureSection load='4zre' size='340' side='right' caption='[[4zre]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4zre' size='340' side='right'caption='[[4zre]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zre]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dandruff-associated_fungus Dandruff-associated fungus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Malassezia_globosa_CBS_7966 Malassezia globosa CBS 7966]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZRE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zrd|4zrd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGL_0797 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=425265 Dandruff-associated fungus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zre OCA], [https://pdbe.org/4zre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zre RCSB], [https://www.ebi.ac.uk/pdbsum/4zre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zre ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zre OCA], [http://pdbe.org/4zre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zre RCSB], [http://www.ebi.ac.uk/pdbsum/4zre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zre ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LIP1_MALGO LIP1_MALGO] Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:17460728, PubMed:18000048). Shows activity against monoglyceride and diglyceride substrates, but not triglyceride substrates and does not exhibit regio-selective production of diacylglycerols (PubMed:17460728, PubMed:22750000, PubMed:25837472, PubMed:25955297, PubMed:26239010, PubMed:26365206, PubMed:27130210). Able to hydrolyze diacylglycerols such as distearin, dilinolein, dipalmitoylglycerol and dipalmitolein (PubMed:27130210). Cleaves oleic acid from 1,2 isomers of diolein on both the 1 and the 2 position of the glycerol backbone, resulting mainly in free fatty acids but no monoolein is detected (PubMed:27130210). Shows activity on monoolein and liberates mostly free fatty acids, but can also perform the reverse reaction and produce diolein (PubMed:27130210).<ref>PMID:17460728</ref> <ref>PMID:18000048</ref> <ref>PMID:22750000</ref> <ref>PMID:25837472</ref> <ref>PMID:25955297</ref> <ref>PMID:26239010</ref> <ref>PMID:26365206</ref> <ref>PMID:27130210</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zre" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zre" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Lipase 3D Structures|Lipase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dandruff-associated fungus]]
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[[Category: Large Structures]]
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[[Category: Hou, S]]
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[[Category: Malassezia globosa CBS 7966]]
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[[Category: Liu, J]]
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[[Category: Hou S]]
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[[Category: Xu, H]]
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[[Category: Liu J]]
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[[Category: Xu, J]]
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[[Category: Xu H]]
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[[Category: Hydrolase]]
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[[Category: Xu J]]
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[[Category: Mono- and diacylglycerol lipase]]
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Current revision

Crystal structure of SMG1 F278D mutant

PDB ID 4zre

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