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4zzy
From Proteopedia
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==Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor== | ==Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor== | ||
| - | <StructureSection load='4zzy' size='340' side='right' caption='[[4zzy]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4zzy' size='340' side='right'caption='[[4zzy]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4zzy]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4zzy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZZY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D7N:2-[1-(4,4-DIFLUOROCYCLOHEXYL)-PIPERIDIN-4-YL]-6-FLUORO-3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDE'>D7N</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zzy OCA], [https://pdbe.org/4zzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zzy RCSB], [https://www.ebi.ac.uk/pdbsum/4zzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zzy ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4zzy" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4zzy" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Borghi | + | [[Category: Large Structures]] |
| - | [[Category: Busel | + | [[Category: Borghi D]] |
| - | [[Category: Caprera | + | [[Category: Busel AA]] |
| - | [[Category: Casale | + | [[Category: Caprera F]] |
| - | [[Category: Ciomei | + | [[Category: Casale E]] |
| - | [[Category: Cirla | + | [[Category: Ciomei M]] |
| - | [[Category: Corti | + | [[Category: Cirla A]] |
| - | [[Category: DAnello | + | [[Category: Corti E]] |
| - | [[Category: Donati | + | [[Category: DAnello M]] |
| - | [[Category: Fasolini | + | [[Category: Donati D]] |
| - | [[Category: Felder | + | [[Category: Fasolini M]] |
| - | [[Category: Forte | + | [[Category: Felder ER]] |
| - | [[Category: Galvani | + | [[Category: Forte B]] |
| - | [[Category: Isacchi | + | [[Category: Galvani A]] |
| - | [[Category: Khvat | + | [[Category: Isacchi A]] |
| - | [[Category: Krasavin | + | [[Category: Khvat A]] |
| - | [[Category: Lupi | + | [[Category: Krasavin MY]] |
| - | [[Category: Montagnoli | + | [[Category: Lupi R]] |
| - | [[Category: Orsini | + | [[Category: Montagnoli A]] |
| - | [[Category: Papeo | + | [[Category: Orsini P]] |
| - | [[Category: Perego | + | [[Category: Papeo G]] |
| - | [[Category: Pesenti | + | [[Category: Perego R]] |
| - | [[Category: Pezzetta | + | [[Category: Pesenti E]] |
| - | [[Category: Posteri | + | [[Category: Pezzetta D]] |
| - | [[Category: Rainoldi | + | [[Category: Posteri H]] |
| - | [[Category: RiccardiSirtori | + | [[Category: Rainoldi S]] |
| - | [[Category: Scolaro | + | [[Category: RiccardiSirtori F]] |
| - | [[Category: Sola | + | [[Category: Scolaro A]] |
| - | [[Category: Zuccotto | + | [[Category: Sola F]] |
| - | + | [[Category: Zuccotto F]] | |
Current revision
Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor
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Categories: Homo sapiens | Large Structures | Borghi D | Busel AA | Caprera F | Casale E | Ciomei M | Cirla A | Corti E | DAnello M | Donati D | Fasolini M | Felder ER | Forte B | Galvani A | Isacchi A | Khvat A | Krasavin MY | Lupi R | Montagnoli A | Orsini P | Papeo G | Perego R | Pesenti E | Pezzetta D | Posteri H | Rainoldi S | RiccardiSirtori F | Scolaro A | Sola F | Zuccotto F
