4rs8

<StructureSection load='4rs8' size='340' side='right' caption='[[4rs8]], [[Resolution|resolution]] 2.29&Aring;' scene=''>

<table><tr><td colspan='2'>[[4rs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_sp._nob8h2 Sulfolobus sp. nob8h2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RS8 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rs7|4rs7]], [[4rsb|4rsb]], [[4rsf|4rsf]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rs8 OCA], [http://pdbe.org/4rs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rs8 RCSB], [http://www.ebi.ac.uk/pdbsum/4rs8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rs8 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Although recent studies have provided a wealth of information about archaeal biology, nothing is known about the molecular basis of DNA segregation in these organisms. Here, we unveil the machinery and assembly mechanism of the archaeal Sulfolobus pNOB8 partition system. This system uses three proteins: ParA; an atypical ParB adaptor; and a centromere-binding component, AspA. AspA utilizes a spreading mechanism to create a DNA superhelix onto which ParB assembles. This supercomplex links to the ParA motor, which contains a bacteria-like Walker motif. The C domain of ParB harbors structural similarity to CenpA, which dictates eukaryotic segregation. Thus, this archaeal system combines bacteria-like and eukarya-like components, which suggests the possible conservation of DNA segregation principles across the three domains of life.

 

Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages.,Schumacher MA, Tonthat NK, Lee J, Rodriguez-Castaneda FA, Chinnam NB, Kalliomaa-Sanford AK, Ng IW, Barge MT, Shaw PL, Barilla D Science. 2015 Sep 4;349(6252):1120-4. doi: 10.1126/science.aaa9046. PMID:26339031<ref>PMID:26339031</ref>

 

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<references/>

[[Category: Sulfolobus sp. nob8h2]]

[[Category: Barilla, D]]

[[Category: Chinnam, N B]]

[[Category: Lee, J]]

[[Category: Schumacher, M A]]

[[Category: Pnob8 parb]]