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5ur7

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==Crystal structure of engineered CCL20 disulfide locked dimer==
==Crystal structure of engineered CCL20 disulfide locked dimer==
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<StructureSection load='5ur7' size='340' side='right' caption='[[5ur7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5ur7' size='340' side='right'caption='[[5ur7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ur7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UR7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ur7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UR7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0004&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ur7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ur7 OCA], [http://pdbe.org/5ur7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ur7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ur7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ur7 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ur7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ur7 OCA], [https://pdbe.org/5ur7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ur7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ur7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ur7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CCL20_HUMAN CCL20_HUMAN]] Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.<ref>PMID:12149255</ref>
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[https://www.uniprot.org/uniprot/CCL20_HUMAN CCL20_HUMAN] Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.<ref>PMID:12149255</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Getschman, A E]]
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[[Category: Homo sapiens]]
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[[Category: Peterson, F C]]
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[[Category: Large Structures]]
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[[Category: Volkman, B F]]
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[[Category: Getschman AE]]
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[[Category: Ccl20]]
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[[Category: Peterson FC]]
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[[Category: Chemokine]]
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[[Category: Volkman BF]]
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[[Category: Chemotaxis]]
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[[Category: Cytokine]]
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[[Category: Immune system]]
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[[Category: Locked dimer]]
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[[Category: Macrophage inflammatory protein-3 alpha]]
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[[Category: Mip3-alpha]]
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[[Category: Psoriasis]]
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Current revision

Crystal structure of engineered CCL20 disulfide locked dimer

PDB ID 5ur7

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