6bly

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(New page: ==Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution== <StructureSection load='6bly' size='340' side='right' caption='6bly, resolution 3.36&Aring;' s...)
Current revision (14:22, 13 March 2024) (edit) (undo)
 
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==Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution==
==Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution==
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<StructureSection load='6bly' size='340' side='right' caption='[[6bly]], [[Resolution|resolution]] 3.36&Aring;' scene=''>
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<SX load='6bly' size='340' side='right' viewer='molstar' caption='[[6bly]], [[Resolution|resolution]] 3.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bly]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BLY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bly]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BLY FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bly OCA], [http://pdbe.org/6bly PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bly RCSB], [http://www.ebi.ac.uk/pdbsum/6bly PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bly ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.36&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bly OCA], [https://pdbe.org/6bly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bly RCSB], [https://www.ebi.ac.uk/pdbsum/6bly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bly ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CPSF1_HUMAN CPSF1_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.<ref>PMID:14749727</ref> [[http://www.uniprot.org/uniprot/WDR33_HUMAN WDR33_HUMAN]] Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.<ref>PMID:19217410</ref>
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[https://www.uniprot.org/uniprot/CPSF1_HUMAN CPSF1_HUMAN] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.<ref>PMID:14749727</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Hamilton, K]]
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[[Category: Homo sapiens]]
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[[Category: Sun, Y]]
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[[Category: Large Structures]]
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[[Category: Tong, L]]
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[[Category: Hamilton K]]
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[[Category: Walz, T]]
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[[Category: Sun Y]]
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[[Category: Zhang, Y]]
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[[Category: Tong L]]
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[[Category: Polyadenylation]]
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[[Category: Walz T]]
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[[Category: Protein binding]]
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[[Category: Zhang Y]]
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[[Category: Scaffolding protein]]
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[[Category: Wd40]]
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Current revision

Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution

6bly, resolution 3.36Å

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