3fhj

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==Independent saturation of three TrpRS subsites generates a partially-assembled state similar to those observed in molecular simulations==
==Independent saturation of three TrpRS subsites generates a partially-assembled state similar to those observed in molecular simulations==
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<StructureSection load='3fhj' size='340' side='right' caption='[[3fhj]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='3fhj' size='340' side='right'caption='[[3fhj]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fhj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FHJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fhj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d2r|1d2r]], [[1mb2|1mb2]], [[1m83|1m83]], [[2ov4|2ov4]], [[1i6k|1i6k]], [[3fi0|3fi0]], [[1mau|1mau]], [[1i6m|1i6m]], [[1i6l|1i6l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trpS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhj OCA], [https://pdbe.org/3fhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhj RCSB], [https://www.ebi.ac.uk/pdbsum/3fhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhj ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan--tRNA_ligase Tryptophan--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.2 6.1.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhj OCA], [http://pdbe.org/3fhj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fhj RCSB], [http://www.ebi.ac.uk/pdbsum/3fhj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhj ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYW_GEOSE SYW_GEOSE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhj_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhj_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3fhj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3fhj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 12980]]
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[[Category: Geobacillus stearothermophilus]]
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[[Category: Tryptophan--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Carter, C W]]
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[[Category: Carter Jr CW]]
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[[Category: Delarue, M]]
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[[Category: Delarue M]]
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[[Category: Kapustina, M]]
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[[Category: Kapustina M]]
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[[Category: Koehl, P]]
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[[Category: Koehl P]]
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[[Category: Laowanapiban, P]]
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[[Category: Laowanapiban P]]
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[[Category: Vonrhein, C]]
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[[Category: Vonrhein C]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Atp-binding]]
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[[Category: Cytoplasm]]
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[[Category: Ligand-dependent domain rearrangement]]
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[[Category: Ligase]]
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[[Category: Mechanistic pathway]]
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[[Category: Molecular simulation]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein biosynthesis]]
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[[Category: Translation]]
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Current revision

Independent saturation of three TrpRS subsites generates a partially-assembled state similar to those observed in molecular simulations

PDB ID 3fhj

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