2bee

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[[Image:2bee.gif|left|200px]]
 
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{{Structure
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==Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site==
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|PDB= 2bee |SIZE=350|CAPTION= <scene name='initialview01'>2bee</scene>, resolution 2.6&Aring;
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<StructureSection load='2bee' size='340' side='right'caption='[[2bee]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=JS4:(2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-4-(2-(3-AMINOPROPYLAMINO)ETHOXY)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,4R,5S,6R)-3-AMINO-4,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-(HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL'>JS4</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[2bee]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JS4:(2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-4-(2-(3-AMINOPROPYLAMINO)ETHOXY)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,4R,5S,6R)-3-AMINO-4,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-(HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL'>JS4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bee OCA], [https://pdbe.org/2bee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bee RCSB], [https://www.ebi.ac.uk/pdbsum/2bee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bee ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1j7t|1J7T]], [[2esi|2ESI]], [[2be0|2BE0]], [[2esj|2ESJ]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bee OCA], [http://www.ebi.ac.uk/pdbsum/2bee PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bee RCSB]</span>
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__TOC__
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}}
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</StructureSection>
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[[Category: Large Structures]]
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'''Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site'''
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[[Category: Francois B]]
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[[Category: Westhof E]]
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==About this Structure==
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2BEE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEE OCA].
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==Reference==
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Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site., Francois B, Szychowski J, Adhikari SS, Pachamuthu K, Swayze EE, Griffey RH, Migawa MT, Westhof E, Hanessian S, Angew Chem Int Ed Engl. 2004 Dec 10;43(48):6735-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15593140 15593140]
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[[Category: Protein complex]]
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[[Category: Francois, B.]]
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[[Category: Westhof, E.]]
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[[Category: a site]]
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[[Category: aa bulge]]
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[[Category: rna-aminoglycoside interaction]]
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[[Category: uou pair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:05:09 2008''
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Current revision

Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site

PDB ID 2bee

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