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4pcw

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==Crystal Structure of the N-terminal Domain of Human Profilaggrin at 2.2 A Resolution==
==Crystal Structure of the N-terminal Domain of Human Profilaggrin at 2.2 A Resolution==
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<StructureSection load='4pcw' size='340' side='right' caption='[[4pcw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4pcw' size='340' side='right'caption='[[4pcw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pcw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PCW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pcw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PCW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FLG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcw OCA], [http://pdbe.org/4pcw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pcw RCSB], [http://www.ebi.ac.uk/pdbsum/4pcw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcw OCA], [https://pdbe.org/4pcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pcw RCSB], [https://www.ebi.ac.uk/pdbsum/4pcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/FILA_HUMAN FILA_HUMAN]] Autosomal dominant ichthyosis vulgaris. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/FILA_HUMAN FILA_HUMAN] Autosomal dominant ichthyosis vulgaris. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FILA_HUMAN FILA_HUMAN]] Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
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[https://www.uniprot.org/uniprot/FILA_HUMAN FILA_HUMAN] Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bunick, C G]]
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[[Category: Large Structures]]
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[[Category: Steitz, T A]]
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[[Category: Bunick CG]]
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[[Category: Ef-hand calcium binding protein]]
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[[Category: Steitz TA]]
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[[Category: Epidermal skin protein]]
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[[Category: Metal binding protein]]
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[[Category: S100 protein]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the N-terminal Domain of Human Profilaggrin at 2.2 A Resolution

PDB ID 4pcw

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