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4qbo

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==VRR_NUC domain==
==VRR_NUC domain==
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<StructureSection load='4qbo' size='340' side='right' caption='[[4qbo]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='4qbo' size='340' side='right'caption='[[4qbo]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qbo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_bacteriophage_p9 Streptococcus bacteriophage p9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QBO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_phage_P9 Streptococcus phage P9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QBO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbo OCA], [http://pdbe.org/4qbo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qbo RCSB], [http://www.ebi.ac.uk/pdbsum/4qbo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbo ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbo OCA], [https://pdbe.org/4qbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qbo RCSB], [https://www.ebi.ac.uk/pdbsum/4qbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbo ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A7J283_9CAUD A7J283_9CAUD]
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FAN1 is a structure-selective DNA repair nuclease with 5' flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair nuclease ("VRR-Nuc") "module" that commonly occurs as a standalone domain in many bacteria and viruses. Crystal structures of three representatives show that they structurally resemble Holliday junction resolvases (HJRs), are dimeric in solution, and are able to cleave symmetric four-way junctions. In contrast, FAN1 orthologs are monomeric and cleave 5' flap structures in vitro, but not Holliday junctions. Modeling of the VRR-Nuc domain of FAN1 reveals that it has an insertion, which packs against the dimerization interface observed in the structures of the viral/bacterial VRR-Nuc proteins. We propose that these additional structural elements in FAN1 prevent dimerization and bias specificity toward flap structures.
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FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.,Pennell S, Declais AC, Li J, Haire LF, Berg W, Saldanha JW, Taylor IA, Rouse J, Lilley DM, Smerdon SJ Cell Rep. 2014 Jul 10;8(1):84-93. doi: 10.1016/j.celrep.2014.06.001. Epub 2014, Jun 26. PMID:24981866<ref>PMID:24981866</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4qbo" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptococcus bacteriophage p9]]
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[[Category: Large Structures]]
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[[Category: Li, J]]
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[[Category: Streptococcus phage P9]]
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[[Category: Pennell, S]]
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[[Category: Li J]]
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[[Category: Smerdon, S J]]
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[[Category: Pennell S]]
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[[Category: Hydrolase]]
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[[Category: Smerdon SJ]]
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[[Category: Nuclease]]
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Current revision

VRR_NUC domain

PDB ID 4qbo

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