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| - | | + | #REDIRECT [[6hl1]] This PDB entry is obsolete and replaced by 6hl1 |
| - | ==FXR with CDCA and NCoA-2 peptide==
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| - | <StructureSection load='4qe6' size='340' side='right' caption='[[4qe6]], [[Resolution|resolution]] 1.65Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qe8|4qe8]]</td></tr>
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| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1H4, BAR, FXR, HRR1, RIP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [http://pdbe.org/4qe6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Human]]
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| - | [[Category: Bamberg, K]]
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| - | [[Category: Dekker, N]]
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| - | [[Category: Kudlinzki, D]]
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| - | [[Category: Linhard, V L]]
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| - | [[Category: Merk, D]]
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| - | [[Category: Nilsson, E]]
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| - | [[Category: Saxena, K]]
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| - | [[Category: Schubert-Zsilavecz, M]]
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| - | [[Category: Schwalbe, H]]
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| - | [[Category: Sreeramulu, S]]
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| - | [[Category: Wissler, L]]
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| - | [[Category: Bile acid receptor dna]]
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| - | [[Category: Receptor]]
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| - | [[Category: Transcription]]
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