4qtj

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==Complex of WOPR domain of Wor1 in Candida albicans with the 13bp dsDNA==
==Complex of WOPR domain of Wor1 in Candida albicans with the 13bp dsDNA==
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<StructureSection load='4qtj' size='340' side='right' caption='[[4qtj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4qtj' size='340' side='right'caption='[[4qtj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qtj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QTJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qtj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QTJ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WOR1, EAP2, TOS9, CaO19.12348, CaO19.4884 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtj OCA], [http://pdbe.org/4qtj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qtj RCSB], [http://www.ebi.ac.uk/pdbsum/4qtj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qtj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtj OCA], [https://pdbe.org/4qtj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qtj RCSB], [https://www.ebi.ac.uk/pdbsum/4qtj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qtj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/WOR1_CANAL WOR1_CANAL]] Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.<ref>PMID:16321041</ref> <ref>PMID:16950924</ref> <ref>PMID:16899543</ref> <ref>PMID:16905649</ref> <ref>PMID:17880264</ref> <ref>PMID:18551173</ref> <ref>PMID:20735781</ref> <ref>PMID:22095082</ref> <ref>PMID:22621896</ref>
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[https://www.uniprot.org/uniprot/WOR1_CANAL WOR1_CANAL] Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.<ref>PMID:16321041</ref> <ref>PMID:16950924</ref> <ref>PMID:16899543</ref> <ref>PMID:16905649</ref> <ref>PMID:17880264</ref> <ref>PMID:18551173</ref> <ref>PMID:20735781</ref> <ref>PMID:22095082</ref> <ref>PMID:22621896</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Canal]]
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[[Category: Candida albicans SC5314]]
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[[Category: Ding, J]]
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[[Category: Large Structures]]
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[[Category: Zhang, S]]
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[[Category: Ding J]]
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[[Category: Zhang, T]]
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[[Category: Zhang S]]
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[[Category: Dna binding domain]]
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[[Category: Zhang T]]
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[[Category: Protein-dna recognition]]
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[[Category: Transcription-dna complex]]
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[[Category: Transcriptional regulation]]
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[[Category: White-opaque switching]]
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[[Category: Wopr domain]]
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[[Category: Wor1]]
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Current revision

Complex of WOPR domain of Wor1 in Candida albicans with the 13bp dsDNA

PDB ID 4qtj

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